Paggiaro AO, Menezes AG, Ferrassi AD, De Carvalho VF, Gemperli R. J Wound Care. 2018;27(Sup2)
Objective:
This systematic review aimed to analyze the scientific evidence on the biological effects of the amniotic membrane in stimulating healing in diabetic foot ulcers (DFUs).
Study Design:
The review included six randomized controlled trials (RCTs) comprising 331 patients with DFUs. The primary outcomes were wound healing proportion and average wound healing time.
Results:
The use of amniotic membrane dressings resulted in a 2.32 times higher likelihood of wound healing compared to conventional dressings. The average wound healing time was reduced by 32.4 days in the amniotic membrane group compared to the control group.
Conclusion:
Amniotic membrane treatment offers superior wound healing rates and faster healing times in patients with diabetic foot ulcers. These findings support the clinical use of amniotic membranes in the treatment of DFUs.
Link to Article:
Biological Effects of Amniotic Membrane on Diabetic Foot Wounds: A Systematic Review