Clinical Case Studies
The Effectiveness of a New Dried Human Amnion Derived Membrane in Treating Diabetic Foot Ulcers
Game F, Gray K, Chokkalingam K, et al. Int Wound J. 2021;18:692-700 Objective:This pilot study aimed to determine if adding a dried human amnion membrane (dHAM) product to standard care would...
Comparing Human Amniotic Allograft and Standard Wound Care with Total Contact Casting for Diabetic Foot Ulcers: A Randomized Clinical Trial
Summary:This prospective, randomized study by Thompson P, Hanson DS, Langemo D, and Anderson J compared the healing effectiveness of human amniotic allograft (HAA) combined with total contact...
A Prospective Randomized Multicenter Clinical Trial on the Use of Aseptically Processed Dehydrated Human Amnion/Chorion Membrane for Healing Diabetic Foot Ulcers
Summary:This randomized, multicenter clinical trial conducted by DiDomenico LA, Orgill DP, Galiano RD, et al. evaluated the efficacy of aseptically processed dehydrated human amnion and chorion...
Biological Effects of Amniotic Membrane on Diabetic Foot Wounds: A Systematic Review
Paggiaro AO, Menezes AG, Ferrassi AD, De Carvalho VF, Gemperli R. J Wound Care. 2018;27(Sup2) Objective:This systematic review aimed to analyze the scientific evidence on the biological effects of...
Amnion Membrane in Diabetic Foot Wounds: A Meta-analysis
Haugh AM, Witt JG, Hauch A, et al. Plast Reconstr Surg Glob Open. 2017;5(4) Objective:This meta-analysis reviewed randomized controlled trials (RCTs) comparing the efficacy of amniotic membrane...
A Multicenter Randomized Controlled Trial of Dehydrated Amniotic Membrane Allograft for Treating Chronic Diabetic Foot Ulcers
Summary:This prospective, randomized, multicenter trial, conducted by Snyder RJ, Shimozaki K, Tallis A, and colleagues, examines the efficacy of using dehydrated amniotic membrane allograft (DAMA)...
Clinical Efficacy and Cost-Effectiveness of Advanced Therapies for Diabetic Lower Extremity Ulcers: A Multicenter Randomized Controlled Trial
Summary:This study, conducted by Zelen CM, Serena TE, Gould L, and colleagues, evaluates the clinical efficacy and cost-effectiveness of bioengineered skin substitutes (BSS) and dehydrated human...
Comparative Effectiveness of EpiFix, Apligraf, and Standard Care for Chronic Diabetic Lower Extremity Ulcers: A Multicenter Randomized Controlled Trial
Summary:This study, conducted by Zelen CM, Gould L, Serena TE, Carter MJ, Keller J, and Li WW, evaluates the healing effectiveness of dehydrated human amnion/chorion membrane (dHACM) allografts...
Weekly vs. Biweekly Application of Dehydrated Human Amnion/Chorion Membrane Allograft for Diabetic Foot Ulcers: A Randomized Comparative Study
Summary: This study by Zelen CM, Serena TE, and Snyder RJ evaluates the efficacy of weekly versus biweekly applications of dehydrated human amnion/chorion membrane (dHACM) allografts in accelerating...
Randomized Controlled Trial of Amniotic Membrane for Diabetic Foot Ulcers: Efficacy and Healing Outcomes
Summary:This randomized controlled trial, conducted by Zelen CM, Serena TE, Denoziere G, and Fetterolf DE, aimed to assess the effectiveness of dehydrated human amniotic membrane allografts (EpiFix)...
Efficacy of Amniotic Membrane Graft for Diabetic Foot Ulcers: A Randomized Controlled Trial
Summary:This study, conducted by Zelen CM, Serena TE, Denoziere G, and Fetterolf DE, explores the effectiveness of a dehydrated human amniotic membrane allograft (EpiFix) in treating diabetic foot...